A tractor-trailer hauling glass overturned on Interstate 77 North near Bluff Road, forcing the closure of the northbound lanes.
The driver, Harold Thomas Bradley, 52, Gaston, was driving north when he lost control and his Freightliner overturned, S.C. Highway Patrol trooper Billy Elder said.
Bradley was not treated for any injuries, Richland County EMS Division Manager George Rice said.
Traffic is being routed off the interstate at Bluff Road, on to Shop Road and then back to the interstate.
The wreck is under investigation by the Highway Patrol.